PROCESS FOR PRODUCING MERCAPTOALKANESULFONATES AND PHOSPHONATES AND DERIVATIVES THEREOF

摘要

A two step single-pot process for producing dimesna (NaSO3-(CH2)2-S-S-(CH2)2-SO3Na) begins by reacting an φ-alkenesulfonate with a sulfide such as NaSH to yield mesna (HS-(CH2)2-SO3Na). (This can be isolated or converted to a C1-4 thioalkyl ether thereof by reaction with sodium alkoxide and an alkyl halide). In the second step, mesna is oxidised in situ with oxygen gas to yield dimesna. Higher alkane homologues and analogous phosphonates are prepared similarly. When preparing a phosphonate analogue a haloalkanephosphonate is an alternative starting compound. The C1-4-alkylene chain analogues of these compounds can be prepared similarly.