| 摘要 |
The present invention provides improved methods for synthesizing phthalocyanines, particularly HOSiPcOSi(CH3)2(CH2)3N(CH3)2, which do not involve photolysis, and which produces purity of at least about 95 %, and in the preferred embodiment of the first method of synthesis provide a yield of greater than about 70 % and typically greater than 80 %. The first method involves a method for synthesizing a phthalocyanine compound comprising the following steps: providing a phthalocyanine precursor having a central silicon; adding a first aminosiloxy ligand to the central silicon of the phthalocyanine precursor adding a second aminosiloxy ligand to the central silicon of the phthalocyanine precursor; displacing the second aminosiloxy ligand by an organic acid ligand, preferably C13CCOO ligand; then displacing the C13CCOO ligand with an HO ligand. The second method for making Pc4 is a method for synthesizing a phthalocyanine compound comprising the following steps: providing a phthalocyanine precursor having a central silicon; providing a siloxy ligand with an iodo group; adding a first and second siloxyiodo ligand to the central silicon of the phthalocyanine precursor; displacing the second siloxyiodo ligand by an organic acid, preferably a C13CCOO ligand; then displacing the C13CCOO ligand with an HO ligand; and then displacing the iodo group with a dimethylamino group. The invention also relates to methods for making two novel phthalocyanine compounds HOSiPcOSi(CH3)2(CH2)3I and SiPc¢OSi(CH3)2(CH2)3I!2, and to the compounds themselves which are useful as dyes and in photodynamic therapy.
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