Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives

摘要

1H-3-aryl-pyrrolidine-2,4-dione derivs. of formula (I), their diastereomer mixts. pure diastereomers and enantiomers are new. A = alkyl, alkenyl, alkoxy, alkyl, alkylthioalkyl (all opt. substd. with halogen) cycloalkyl (opt. interrupted with at least one heteroatom and opt. substd.), aryl, arylalkyl or heteroaryl (these last 3 gps. each opt substd. with halogen, alkyl, haloalkyl, alkoxy or NO2) or H; B = H, alkyl or alkoxyalkyl; or CAB = opt satd. ring (opt. interrupted with at least one heteroatom and opt. substd.); X = halogen or alkyl; when X = halogen then Y alkyl; when X = alkyl then Y = halogen; G = H, a metal ion equivalent, an ammonium ion, COR1, C(=L)-MR2, SO2R3, P(=L)R4R5 or C(=L)-NR6R7; L, M = O or S; R1 = alkyl, alkenyl, alkoxy, alkyl, alkylthioalkyl, polyoxyalkyl (all opt. substd. with halogen), cycloalkyl (opt. substd. with halogen or alkyl and opt. interrupted with at least one heteroatom) Ph, phenylalkyl, heteroaryl, phenoxyalkyl or heteroaryloxyalkyl (these last 5 each opt. substd); R2 = alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl (all opt. substd. with halogen), cycloalkyl, Ph or benzyl (these 3 each opt. substd); R3-R5 = alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenylthio, cycloalkylthio (all opt. substd. with halogen), Ph, OPh or SPh (these 3 each opt. substd); R6 and R7 = alkyl, cycloalkyl, alkenyl, alkoxy, alkoxyalkyl (all opt. substd. with halogen), Ph or benzyl (both opt. substd) or H; or NR6R7 = heterocycle opt. interrupted with O or S.