摘要 |
The invention relates to a process for the production of carbacyclins of formula I (see fig.I) in which R1 can be a straight-chain or branched C1-C7 alkyl group, a straight-chain or branched C2-C7 alkenyl group or a straight-chain or branched C2-C7 alkinyl group and R2, R3 can be the same or different and can mean hydrogen, C1-C2-alkyl, chlorine or bromine or, together with the double bond, a triple bond, characterized in that a bicyclic ketone of formula II (see fig.II) in which R1, R2 and R3 have the meanings indicated above, is reacted with 5-10 equivalents of a reagent of formula VI (VI), in the presence of 8-12 equivalents of a base, at 0-40.degree. for 0.5 to 4 hours in the solvents dimethoxyethane, 1,3-dimethylimidazolidin-2-one, dimethylformamide, dimethyl-sulfoxide, tetrahydrofuran, toluene, dibenzo-18-crown-6 or in their mixtures.
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