发明名称 EFFERVESCENT TABLET AND EFFERVESCENT SYSTEM FOR EFFERVESCENT GRANULES, AND MANUFACTURE OF THE SAME SYSTEM
摘要 PROBLEM TO BE SOLVED: To provide a effervescent system having improved stability greatly as possible, concerning the generation of carbon dioxide and decomposition of acetylsalicylic acid as compared with a conventional method. SOLUTION: This effervescent system contains granules of a kind of solid organic food acid and at least one kind of bicarbonate salt of an alkali metal, and the surface of particles the of alkali bicarbonate is changed into at least 1wt.%, preferably 2 or 4wt.%, maximum 10wt.%. preferably <=8wt.% of dried alkali carbonate free from water of crystallization. The acid particle, preferably particles of citric acid, themselves may be coated by a reaction of a kind of carbonate and/or a bicarbonate in the conventional method. To obtain the prescribed change, a commercial alkali bicarbonate particle is heat treated at >=60 deg.C under <=40mbar, preferably <=20mbar in a vacuum container, after passing on the prefixed time for the required thickness of the layer, cooled to the temperature at <=60 deg.C while keeping the vacuum.
申请公布号 JPH1087479(A) 申请公布日期 1998.04.07
申请号 JP19970163918 申请日期 1997.06.20
申请人 GERGELY GERHARD DR 发明人 GERGELY GERHARD DR;GERGELY IRMGARD;GERGELY THOMAS DR;GERGELY STEFAN DR
分类号 A23L2/00;A23L1/00;A23L2/40;A61K9/46;C01B31/24 主分类号 A23L2/00
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