GLYCOPEPTIDE ANTIBIOTICS

摘要

A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.