| 摘要 |
PROBLEM TO BE SOLVED: To profitably obtain the subject compound useful as a raw material for an oxazolidinedione derivative used as a diabetic medicine, etc., by reducing a specific ketonic acid in the presence of a baker's yeast and a hydrolase inhibitor. SOLUTION: This method for producing an optically active compound comprises reducing a compound of formula I [R is a (substituted)hydrocarbon or heterocyclic group; Y is CO, CH(OH), NR<3> (R<3> is a 1-4C alkyl); (m) is 0, 1; (n) is 0, 1, 2; R<1> , R<4> are each H, a 1-4C alkyl; A is a divalent 1-7C aliphatic hydrocarbon group; the ring E is benzene ring which may have one or two substituents] e.g. 5-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3- methoxyphenyl]-2-oxopentanoic acid ethyl ester} in the presence of a baker's yeast and a hydrolysis inhibitor (e.g. butane sulfonyl fluoride). The objective optically active compound of formula II can thereby efficiently be obtained in the simple operation. |
