COMPOSITION PHARMACEUTIQUE A LIBERATION MODIFIEE DE PRINCIPE ACTIF, COMPORTANT UNE MATRICE, ET PROCEDE DE FABRICATION

摘要

The invention concerns a method for preparing a pharmaceutical composition with modified release of the active principle, comprising an active principle, a lipidic matrix agent and an additive characterised in that it consists in the following steps: while heating and fluidising, mixing a powder of one constituent selected among the group comprising the active principle and the additive; separately, hot liquefying said lipidic matrix agent; then coating said powder, by pulverising said lipidic matrix agent on the individualised granules; and finally lowering the temperature so as to enable the solidification of the lipidic matrix agent.