发明名称 |
THREE COMPONENT CHIMERIC ANTISENSE OLIGONUCLEOTIDES |
摘要 |
The present application describes a novel family of oligonucleotide compounds having a novel organization of various modified nucleotides and modified chemical linkages. The application further discloses that limiting the presence and extent of specific modified nucleotides/modified linkages in the oligomers results in enhanced activation of endogenous RNase H activity.
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申请公布号 |
CA2266748(A1) |
申请公布日期 |
1998.04.02 |
申请号 |
CA19972266748 |
申请日期 |
1997.09.26 |
申请人 |
OLIGOS ETC. INC.;WOOLF, TOD M. |
发明人 |
DALE, RODERIC M. K.;ARROW, AMY;WOOLF, TOD M. |
分类号 |
C12N15/09;A61K31/7125;A61K48/00;C07H21/00;C12N15/113;(IPC1-7):C07H21/00;A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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