发明名称 METHODS FOR OPTIMIZATION OF GENE THERAPY BY RECURSIVE SEQUENCE SHUFFLING AND SELECTION
摘要 The invention provides methods of evolving nucleic acids for use in gene therapy by recursive sequence recombination. Many of the methods evolve vectors, both viral and nonviral, to have improved properties. For example, vectors are evolved to have improved properties of viral titer, infectivity, expression of a gene within a vector, tissue specificity, viral genome capacity, episomal retention, lack of immunogenicity of the vectors or an expression product thereof, site-specific integration, increased stability, or capacity to confer cellular resistance to microorganism infection. The invention further provides an isolated O<6>-methylguanine-DNA methyltransferase (MGMT) enzyme.
申请公布号 WO9813485(A1) 申请公布日期 1998.04.02
申请号 WO1997US17302 申请日期 1997.09.26
申请人 MAXYGEN, INC.;STEMMER, WILLEM, P., C.;VAN ES, HELMUTH, H., G. 发明人 STEMMER, WILLEM, P., C.;VAN ES, HELMUTH, H., G.
分类号 A61K38/45;A61K48/00;C07K14/47;C12N7/00;C12N9/10;C12N15/10;(IPC1-7):C12N15/00;C12Q1/68 主分类号 A61K38/45
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