Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

摘要

Nucleic acid encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically alpha 4 and alpha 7) and beta subunits (specifically beta 4) are provided. In addition, combinations of subunits (i.e., alpha 1, alpha 2, alpha 3, alpha 4, and/or alpha 7 subunits in combination with beta 4 subunits; or beta 2, beta 3 and/or beta 4 subunits in combination with alpha 4 and/or alpha 7 subunits) are provided.