DEVICE FOR OPTICAL AND ELECTROCHEMICAL MEASUREMENTS IN MICROLITER SIZE SAMPLES

摘要

A small liquid sample to be tested is contained within an annulus (18) on the upper surface (14) of a substrate (12). A reagent diffuses into the sample through a membrane (28) in a junction hole (26), the junction hole connecting upper (14) and lower (16) surfaces of the substrates. Optical measuring equipment (70, 72) detects a measurable change in an optical property of the sample. Alternatively, flow of gas (30) directed at a small liquid sample (24), contained within an annulus on the surface (14) of a substrate (12), causes the sample to flow in a controlled manner over the surface of an electrode (20), disposed on the substrate surface (14). In another alternative, an electrode (20) is disposed in a non-homogeneous sample (24).