| 摘要 |
<p>Described are a process for determining the activity of APP secretase using cellular model systems, those cellular systems being used directly for screening for pharmacological modulators of amyloid βA4 release, and the modulators that can be identified and isolated by that process as pharmaceutical agents for the treatment of Alzheimer's disease. Also described are expression vectors, cells transfected with the expression vectors and the use thereof in the identification of APP secretase modulators, and a kit for determining APP secretase activity.</p> |
