New sulphonamide derivatives of chroman

摘要

Chromans of formula (I) and their salts are new: where R(1), R(2) = H, fluoroalkyl, 1-6C alkyl, optionally substituted phenyl; or R(1) and R(2) = 2-10C alkyl chain; R(3) = substituted alkylsulphonamide; R(4) = substituted 1-20C alkyl; R(5), R(6), R(7), R(8) = H, halogen, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, amido, ester, substituted alkyl-sulphone, -ketone, -amine, -ether, or -amide, optionally substituted phenyl; where R(6) <9> OCF3 or OC2F5. Also claimed are compounds of formula (Ia): where R(A) = H, OH, O(CO)-(1-4C alkyl), O(SO2)-(1-4C alkyl); R(B) = H; or R(A) and R(B) = a bond; R(1) -R(4) = as for (I);and R(C) = CN, 1-6C acyl, F, Cl, Br, I, NO2, 1-6C alkyl.