| 摘要 |
FIELD: biologically-active compounds. SUBSTANCE: new N- substituted 3-azabicyclo[32.0] heptane derivatives with formula I (presented in description) are provided, where R is phenyl or thienyl optionally monosubstituted by nitro, amino, mono- or dimethylamino group; A is group of formula II wherein R is hydrogen, R hydrogen or R and R together form oxygen atom; R optionally fluoro- or chloro-substituted thienyl or naphthyl; R hydrogen or methyl; R phenyl disubstituted by fluorine or fluorine, monosubstituted by amino, C<SB>1</SB>-C<SB>4</SB>-alkylamino, or di-C<SB>1</SB>-C<SB>4</SB>-dialkylamino, or thienyl, naphthyl, benzofuryl, benzothienyl, indolyl, N-methylindolyl, N-methylindenyl, or C<SB>3</SB>-C<SB>6</SB>- cycloalkyl each optionally substituted by fluorine or chlorine atoms; R hydrogen, fluorine, chlorine, C<SB>1</SB>-C<SB>4</SB>-alkyl, or amino group; R hydrogen or methyl; R hydrogen or methyl, or R and R together with annular carbon atom form spiro-cyclopropane ring; R phenyl, benzyl, or cyano group; and n=1,2,3 or 4; and their salts with physiologically tolerable acids. Compounds I function as D<SB>4</SB> dopamine receptor antagonists and can be utilized as neuroleptics and brain-protection drugs. EFFECT: extended choice of neuroleptics. 2 cl, 56 ex
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