Use of tri:alkyl-xanthine or derivatives for modulating apoptosis

摘要

Use of compounds of formula (I) and their isomers is claimed for modulation of apoptosis. R1 = 1-4C alkyl; one of R1, R3 = 1-8C n-alkyl, (CH2)nCOCH3 or (CH2)nC(R4)(OH)CH3; the other of R1, R3 = H, 1-7C alkyl, 4-8C cycloalkyl, 2-6C alkyl interrupted by O; n = 1-6; R4 = H or 1-3C alkyl. Also claimed is a combination preparation containing (I) and compounds of formula (IV) and/or (V) or their stereoisomers or salts for modulation of apoptosis. R5 = 1-4C alkyl, 3-5C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl; R6 = CF3, OCF3, SCF3, OH, NO2, halo, benzyl, phenyl, CN or phenoxy (optionally substituted by 1-4C alkyl, halo, OCF3 or OCH3); R7 = 1-4C alkyl, halo or H; and X = CH or N.