| 摘要 |
PCT No. PCT/EP97/04705 Sec. 371 Date Mar. 10, 1999 Sec. 102(e) Date Mar. 10, 1999 PCT Filed Aug. 29, 1997 PCT Pub. No. WO98/11081 PCT Pub. Date Mar. 19, 1998The present invention relates to a novel process for the preparation of nizatidine, N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, and pharmaceutically acceptable salts thereof, comprising reacting a compound of formula II with a compound of formula III or a salt thereof, in which X represents a leaving group, in the presence of methylamine in the presence of an inert diluent. |
