DEBLOCKING THE COMMON PATHWAY OF AROMATIC AMINO ACID SYNTHESIS.
摘要
Enhanced efficiency of production of aromatic compounds via the common pathway, as shown in the figure, of a host cell is realized by increasing the expression of enzyme species acting on substrate intermediates in identified rate-limiting reaction steps in the pathway. Host cells are transformed with recombinant DNA encoding for the rate-limiting enzymes to provide cell transformants characterized by capacity to produce high concentrations of aromatic metabolites when grown in cell culture with a metabolizable carbon source.
申请公布号
EP0675954(A4)
申请公布日期
1998.04.01
申请号
EP19940905362
申请日期
1993.12.09
申请人
PURDUE RESEARCH FOUNDATION;GENENCOR INTERNATIONAL, INC.
发明人
FROST, JOHN, W.;DELL, KRISTI, A.;DRATHS, KAREN, M.;BERRY, ALAN