| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new nucleic acid coding for MurA-1 polypeptide having a specific amino acid sequence and used for the production, etc., of a compound useful for the development of a therapeutic agent for an infection, a functional failure and a disease related a to Streptococcus pneumoniae. SOLUTION: This isolated new polynucleotide contains a member selected from (A) a polynucleotide at least 60% similar to a polynucleotide coding for a polypeptide having an amino acid sequence 1-427 expressed by the formula, (B) a polynucleotide complimentary to the polynucleotide of (A), and (C) a polynucleotide having at least 15 consecutive bases of the polynucleotides (A) or (B), and is used for the production, etc., of MurA-1 protein useful for the screening of a compound having an antibiotic activity to an infection, a functional failure and a disease related to Streptococcus pneumoniae, and the treatment of the bacterial infection, etc. |
