| 摘要 |
PCT No. PCT/US94/14083 Sec. 371 Date Jun. 13, 1996 Sec. 102(e) Date Jun. 13, 1996 PCT Filed Dec. 7, 1994 PCT Pub. No. WO95/16657 PCT Pub. Date Jun. 22, 1995The invention is directed to an improved process for the preparation of spirocyclic lactams which utilizes diiodides in the spiro alkylation of lactams N-substituted with a tertiary amine group. The resultant spirocyclic lactams are useful in the production of various substituted azaspiranes which are useful as immunomodulatory agents.
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