发明名称 |
Therapeutic inhibitor of vascular smooth muscle cells |
摘要 |
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
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申请公布号 |
US5733925(A) |
申请公布日期 |
1998.03.31 |
申请号 |
US19960738733 |
申请日期 |
1996.10.28 |
申请人 |
NEORX CORPORATION |
发明人 |
KUNZ, LAWRENCE L.;KLEIN, RICHARD A.;RENO, JOHN M.;GRAINGER, DAVID J.;METCALFE, JAMES C.;WEISSBERG, PETER L.;ANDERSON, PETER G. |
分类号 |
A61K9/00;A61K31/00;A61K31/135;A61K31/138;A61K31/337;A61K31/40;A61K31/4025;A61K31/4035;A61K31/407;A61K47/48;(IPC1-7):A61K31/335 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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