发明名称 |
Methods and materials for the diagnosis and treatment of conditions such as stroke |
摘要 |
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the concurrent reaction of such lipid materials with reducing sugars such as glucose, advanced glycosylation endproducts such as AGE-peptides, or a compound which forms advanced glycosylation endproducts, to form materials or particles known as AGE-lipids. AGE-lipids have been implicated in the aging process, the abnormal formation of lipofuscin and in various disease states such as diabetes, atherosclerosis, and stroke. Methods of treating stroke, and especially inhibiting the infarct size of stroke, using agents which inhibit the formation of AGE-lipids are disclosed. Additionally, a method of screening for neuroprotective agents which can be used to reduce the size and severity of the infarct size is disclosed.
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申请公布号 |
US5733933(A) |
申请公布日期 |
1998.03.31 |
申请号 |
US19950473009 |
申请日期 |
1995.06.07 |
申请人 |
THE PICOWER INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
BUCALA, RICHARD J.;VLASSARA, HELEN;CERAMI, ANTHONY;TRACEY, KEVIN J. |
分类号 |
A61K31/155;A61K38/17;A61K39/00;A61Q11/00;C07K16/28;G01N33/573;G01N33/92;(IPC1-7):A61K31/155 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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