Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer

摘要

PCT No. PCT/SE93/00793 Sec. 371 Date May 20, 1994 Sec. 102(e) Date May 20, 1994 PCT Filed Oct. 1, 1993 PCT Pub. No. WO94/07510 PCT Pub. Date Apr. 14, 1994A composition comprising coagulation factor VIII and a non-ionic surfactant such as block copolymers, e.g., polyoxamers or polyoxyethylene (20) sorbitan fatty acid esters, e.g., polysorbate 20 or polysorbate 80 as stabilizer is provided. The composition can also comprise sodium chloride, calcium chloride, L-histidine and/or sugars or sugar alcohols.