Photo-induced DNA-cleaving agents

摘要

The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: <IMAGE> (I) wherein R is C1-C6 alkyl, phenyl, C1-C6 alkoxy, phenoxy, C1-C6 alkoxycarbonyl, halogen or halo(C1-C6 alkyl)wherein R1 is hydrogen, C1-C6 alkyl, phenyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, halogen or halo(C1-C6 alkyl); R2 is hydrogen; R3 is hydrogen or phenyl; R4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O2 to form HOx radicals under irradiation of UV light for a period of 2-3 hours. The HOx radicals then react with DNA to accomplish cleavage of DNA.