DC 107 derivatives and treatment methods

摘要

PCT No. PCT/JP96/01646 Sec. 371 Date Apr. 17, 1997 Sec. 102(e) Date Apr. 17, 1997 PCT Filed Jun. 14, 1996 PCT Pub. No. WO97/00260 PCT Pub. Date Mar. 1, 1997DC107 derivatives represented by the formula (I): <IMAGE> (I) or pharmacologically acceptable slats thereof, [wherein R1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR4 or the like; R2 represents hydrogen or COR5; R3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR6, with the proviso that the compound wherein R1, R2 and Z each represents hydrogen, R3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.