| 摘要 |
The invention describes how to produce compounds of Formula I: wherein: R1 means methyl or ethyl; R2 means -CF3, -CCIF2, -CCI2F or -C2F5; Q is a group, and remaining substituents have the meaning given in Formula I, by which a compound of Formula II: wherein Q has the meaning given in Formula I, is reacted at a temperature of -5 degree C to +40 degree C, with an enamine of Formula III: wherein R1 and R2 have the meanings given in Formula I, and R19 means alkyl from 1 to 6 carbon atoms, in pure dimethyl formamide, dimethyl sulfoxide, acetonitrile, propionitrile, ethyl acetate, tetrahydrofuran, dioxane, N-methyl pyrrolidone, methyl tertiary butyl ether, dimethyl acetamide or toluene, or mixtures thereof as solvents, in presence of 0.2 to 0.4 equivalents of a base selected from potassium tertiary butylate, sodium tertiary butylate, sodium methylate, sodium ethylate, potassium methylate, potassium ethylate, sodium hydride, potassium hydride, sodium pentylate, potassium pentylate, and 1,8-diazabicycle[5.4.0]undec-7-ene (DBU).
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