PROCEDURE FOR PREPARATION OF PAROXETIN-HYDROCHLORID-HEMIHYDRATE FROM PAROXETIN-BASE

摘要

Preparation of paroxetine hydrochloride hemihydrate comprises dissolving paroxetine ((3S-trans-3-[(1,3-benzodioxol-5-yloxy)-methyl]-4-(4-fluorophenyl) piperidine) in a 1-3C alkanol and adjusting the pH to >7 in an aqueous chloride solution.