发明名称 |
HIGH PURITY N-(4-[N,N-BIS(2-IODOETHYL)AMINO]PHENOXYCARBONYL)-L-GLUTAMIC ACID |
摘要 |
PCT No. PCT/GB95/02997 Sec. 371 Date Jun. 23, 1997 Sec. 102(e) Date Jun. 23, 1997 PCT Filed Dec. 21, 1995 PCT Pub. No. WO96/20169 PCT Pub. Date Jul. 4, 1996A new salt of a prodrug useful in antibody directed enzyme prodrug therapy (ADEPT) is disclosed. A hydrogen iodide salt of the prodrug N-(4-[N,N-bis(2-iodoethyl)amino]phenoxycarbonyl)-L-glutamic acid is prepared which can be obtained in crystalline form. Preparation of the crystalline form of the prodrug enables preparation of the prodrug in highly pure form. |
申请公布号 |
HUT77288(A) |
申请公布日期 |
1998.03.30 |
申请号 |
HU19970002207 |
申请日期 |
1995.12.21 |
申请人 |
ZENECA LIMITED |
发明人 |
DINES,SUSAN;DOWELL,ROBERT IAN;HEATON,DAVID WILLIAM |
分类号 |
A61K31/215;A61P43/00;C07C269/06;C07C271/54 |
主分类号 |
A61K31/215 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|