| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for industrially and advantageously producing (R)-2-hydroxy-4-phenyl-3-butenoic acid useful as an intermediate, etc., for a medicine by acting a microorganism belonging to Leuconostoc oenos species and having asymmetrically reducing ability of 2-oxo-4-phenyl-3-butenoic acid on the 2-oxo-4-phenyl-3-butenoic acid. SOLUTION: The objective (R)-2-hydroxy-4-phenyl-3-butenoic acid useful as an important intermediate, etc., for various medicines and an optically and pharmaceutically active material, its derivative, etc., is industrially and advantageously produced by acting a microorganism (e.g. Leuconostoc oenos ATCC 27310) selected from microorganisms belonging to Leuconostoc oenos species having an ability capable of asymmetrically reducing 2-oxo-4-phenyl-3-butenoic acid to (R)-2-hydroxy-4-phenyl-3-butenoic acid on the 2-oxo-4 phenyl-3-butenoic acid and collecting the oroduct. |
