发明名称 |
Attachment-elements for stimulation of eukaryotic expression systems |
摘要 |
The invention concerns methods to increase the expression of genes brought into eukaryotic cells or organisms. By flanking a transcription unit EPC made up by e.g. an enhancer (E), promoter (P), and the (structural) gene of interest (C) with attachment-elements (A) the expression of said (structural) gene of interest is stimulated when integrated into the genome of eucaryotic cells and is independent of its chromosomal position. Thus a construct AEPCA is advantageous because it constitutes an independant regulatory unit.
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申请公布号 |
US5731178(A) |
申请公布日期 |
1998.03.24 |
申请号 |
US19950451308 |
申请日期 |
1995.05.26 |
申请人 |
BEHRINGWERKE AKTIENGESELLSCHAFT |
发明人 |
SIPPEL, ALBRECHT E.;STIEF, ARIBERT |
分类号 |
C12N15/67;C12N15/90;(IPC1-7):C12N15/11;C12N15/85;C12P21/02 |
主分类号 |
C12N15/67 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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