| 摘要 |
New RAR selective retinoid agonists of formula (I) wherein the symbols are a s defined in the specification, and pharmaceutically active salts of carboxyli c acids of formula (I), further the invention relates to the use of such retinoic acid receptor agonists, particularly retinoic acid receptor .gamma.(RAR.gamma.) selective agonists for the treatment of emphysema and associated pulmonary diseases, as well as for the therapy and prophylaxis of dermatological disorders, for the therapy and prophylaxis of malignant and premalignant epithelial lesions, tumours and precancerous changes of the mucous membrane in the mouth, tongue, larynx, oesophagus, bladder, cervix an d colon.
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