发明名称 2-cyano-3, 5-dihydroxyhex-2-enecarboxamide derivatives
摘要 2-Cyano-3,5-dihydroxy-hex-2-ene carboxylic acid amides of formula (I), their stereoisomers and salts are new. R1 = H or 1-4C alkyl; R2 = 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, 3-7C cycloalkyl, a 4-7 membered heterocycle with 1 or 2 heteroatoms (O, N or S); phenyl (optionally once to threefold substituted by 1-4C alkyl, halo, CN, CF3, 1-4C alkoxy (itself optionally substituted by phenyl) or methylenedioxy); or 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl each mono-substituted by phenyl or a group of formula (i); or R1+R2 = O; R3 = H, CF3, OCF3, SCF3, OH, NO2, halo, benzyl, phenyl or CN; or is phenoxy optionally substituted by one or more 1-4C alkyl, halo, OCF3 or OCH3; R4 = H, 1-4C alkyl or halo; R5, R6 = H or 1-4C alkyl; n = 0-4.
申请公布号 AU3748697(A) 申请公布日期 1998.03.19
申请号 AU19970037486 申请日期 1997.09.10
申请人 HOECHST AKTIENGESELLSCHAFT 发明人 WILFRIED SCHWAB;RUTH RAISS
分类号 A61K31/275;A61K31/34;A61K31/341;A61K31/38;A61K31/381;A61K31/44;A61K31/4406;A61K31/4409;A61K31/52;A61K31/522;A61P1/02;A61P3/00;A61P29/00;C07C7/00;C07C255/20;C07C255/23;C07C255/41;C07C255/57;C07C255/59;C07C323/41;C07D213/56;C07D213/57;C07D307/42;C07D307/54;C07D317/60;C07D333/24;C07D333/26;C07D473/04;C07D473/06 主分类号 A61K31/275
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