摘要 |
PCT No. PCT/NL93/00061 Sec. 371 Date Nov. 4, 1994 Sec. 102(e) Date Nov. 4, 1994 PCT Filed Mar. 15, 1993 PCT Pub. No. WO93/17713 PCT Pub. Date Sep. 16, 1993Use of alpha -hydroxy acids and poly- alpha -hydroxy acids as spacer between a therapeutically and/or diagnostically active compound and a soluble macromolecular carrier in pharmaceutical compositions having site-specific delivery. In one embodiment glycolic acid, L-lactic acid or tetra-L-lactic acid is used as spacer between a non-steroidal anti-inflammatory substance and a carrier of low molecular protein (LMWP). |
申请人 |
RIJKSUNIVERSITEIT TE GRONINGEN, GRONINGEN, NL |
发明人 |
FRANSSEN, ERIK, JOHANNES, FRANCISCUS, NL-9722 KN GRONINGEN, NL;MOOLENAAR, FRITS, NL-9999 XG STITSWERD, NL;MEIJER, DIRK, KLAAS, FOKKE, NL-9724 AN GRONINGEN, NL;DE ZEEUW, DICK, NL-9722 BG GRONINGEN, NL |