NEW PDE IV INHIBITORS: BIS-COMPOUNDS

摘要

Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard to, e.g., PDE V inhibition. Also provided is a process of making compounds of Formula (I). Compounds of the present invention are represented by Formula (I), its pharmaceutically acceptable salts, hydrochloride salts, or prodrug forms thereof, wherein: X1a, X1b are independently selected from -NH and -N-lower alkyl, X2a, X2b are optionally present and are independently selected from S(O)n, O, CH2, and NH; P1a, P1b, P2a, P2b, P4a and P4b are independently selected from N, or CH; R1a, R1b, R2a, R2b, R3a and R3b are independently selected from H, C1-C6 alkyl, C3-C6 branched alkyl, C3-C6 cycloalkyl, said alkyl groups being optionally substituted with halogen, aryl or heteroaryl group(s), said aryl and heteroaryl group(s) being optionally substituted with hydroxy, alkoxy, cycloalkoxy, halogen, alkyl, or cycloalkyl; and n is an integer from 0 to 2.