发明名称 |
Protein inhibitor of neuronal nitric oxide synthase |
摘要 |
An nNOS associated protein designated PIN-1 (Protein Inhibitor of nNOS) has been identified. It physically interacts with nNOS and inhibits its activity. Multiple lines of evidence indicate that PIN-1 is a regulator of nNOS: it is physiologically associated with nNOS, and it inhibits its catalytic activity. The extraordinary evolutionary conservation of PIN-1 and preliminary evidence that it interacts with multiple proteins, suggests that it may be a major biological regulatory protein influencing numerous physiological processes. |
申请公布号 |
AU4330197(A) |
申请公布日期 |
1998.03.19 |
申请号 |
AU19970043301 |
申请日期 |
1997.08.29 |
申请人 |
JOHNS HOPKINS UNIVERSITY |
发明人 |
SOLOMON H. SNYDER;SAMIE R. JAFFREY |
分类号 |
G01N33/50;C07K14/47;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12Q1/00;C12Q1/26;G01N33/15;G01N33/53 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|