摘要 |
Pharmaceutical compositions especially for internal application, in a form of drug delivery systems which create the lyotropic liquid crystals when in contact with aqueous phase. The pharmaceutical compositions consist of: (A) hydrophobic active ingredient with immunomodulatory effect from a group of N-methylated cyclic undecapeptides or macrolide antibiotics, in quantity 1,0-35,0 weight % in a carrier medium containing (B) at least one absorption promoter allowing for contact of the drug with a biological membrane or passing of the drug through in quantity 1-40 weight %; (C) nonlipidic vehicle containing at least one of the below-mentioned substances: (C1) surfactant or mixed surfactant with HLB > 9, in quantitiy 1-80 weight %; (C2) lipophilic solvent from group of higher fatty alcohols in quantity 1-30 weight %; (C3) at least one cosurfactant in quantity 1-50 weight %, while a ratio among the individual components of the product is A:B:C = 1:0.5-4:5-8.
|
申请人 |
GALENA AS;STUCHLIK, MILAN;JEGOROV, ALEXANDER;HUSEK, ALES;MATHA, VLADIMIR;STUCHLIK, JOSEF;ANDRYSEK, TOMAS |
发明人 |
STUCHLIK, MILAN;JEGOROV, ALEXANDER;HUSEK, ALES;MATHA, VLADIMIR;STUCHLIK, JOSEF;ANDRYSEK, TOMAS |