摘要 |
This invention is directed to benzamidine derivatives substituted by cyclic amico acid and cyclic hydroxy acid derivatives which are useful as anticoagulants as represented by formulae (I), (II), (III), (IV), (V), (VI), (VII) wherein: A is -C(R8)= or -N=; Z1 and Z2 are independently -O-, -N(R9)-, -S-, S(O)-, -S(O)2-, or -OCH2-; R2 is -C(NH)NH2, -C(NH)N(H)OR9, -C(NH)N(H)C(O)OR12, -C(NH)N(H)C(O)R9, -C(NH)N(H)S(O)2R12, or -C(NH)N(H)C(O)N(H)R9; R7 is -N(R9)- (C(R9)(R10))n-R13 (where n is 0 to 4), -O-(C(R9)(R10))n-R13 (where n is 0 to 4), or -N(R14)R15; R1 and R3 - R6 are as defined in the description. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
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