Stable solution of benzthiazide (3-{8 benzythiol methyl{9 -6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) suitable for parenteral administration and process of preparation

摘要

A clear, stable solution of benzthiazide suitable for medical application has benzthiazide dissolved in an aqueous polyethylene glycol vehicle. The solution has a pH in the range of from about 3 to 6. The solution is prepared by mixing the benzthiazide in polyethylene glycol, stirring until the benzthiazide is dissolved, diluting with water, and adjusting the pH to between about 3 to 6. A benzyl alcohol preservative may be added if desired.