摘要 |
<p>Compounds of formula I useful for inhibiting the pain enhancing effects of E-type prostaglandins are disclosedwherein A is a ring system in which the -CH(R3)N(R2)B-R1 and -OR4 groups are positioned in a 1,2 relationship to one another on ring carbon atoms. B is a ring system having R1 in a 1,3 or 1,4 relationship with the -CH(R1)N(R2)- linking group. A, B, R1, R2, R3 and R4 are as defined in the specification and may be substituted. Also disclosed are pharmaceutically-acceptable salts, in vivo-hydrolysable esters and amides of compounds of formula I, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and the use of such compounds as therapeutic agents.</p> |