| 发明名称 |
PRODUCTION OF PURIFIED BIOLOGICALLY ACTIVE, BACTERIALLY PRODUCED RECOMBINANT HUMAN CSF-1 |
| 摘要 |
A process for recovering dimeric, biologically active CSF-l from bacterially expressed recombinant CSFl genes is described. The process comprises recovery of the solubilized monomeric form, followed by dimerization under refolding conditions and further purification of the dimer. Heterodimers may also be produced by this process.
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| 申请公布号 |
CA1339757(C) |
申请公布日期 |
1998.03.17 |
| 申请号 |
CA19880564327 |
申请日期 |
1988.04.15 |
| 申请人 |
CHIRON CORPORATION |
发明人 |
HALENBECK, ROBERT F.;KOTHS, KIRSTON E.;COWGILL, CYNTHIA;LAIRD, WALTER J. |
| 分类号 |
A61K38/00;A61K38/19;C07K1/113;C07K1/16;C07K14/53;C12N15/27;C12P21/02;(IPC1-7):C07K14/53 |
主分类号 |
A61K38/00 |
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