摘要 |
PROBLEM TO BE SOLVED: To obtain a novel compound which can manifest sufficient antihyperlipemic action with (almost) no cytotoxicity and is useful for treatment of liposis and disorder of lipid metabolism. SOLUTION: This novel compound is represented by formula I [R<1> is H, an (F-substituted) 1-8C alkyl; R<3> is an -O-F-substituted 1-8C alkyl, an -S-F- substituted 1-8C alkyl; R<2> is H, F, Cl, Br, R<3> and R<2> may be incorporated to form an -O-F-substituted 1-5C alkylene-O-] or its acid adduct, typically 4- amino-2-(4,4-dimethylimidazolidin-2-one-1-yl)-5-[N-methly-N-(2-trifluo romethoxy) phenyl]pyrimidine-carboxamide. The compound of formula I is prepared by converting 4-amino-2-(4,4-dimethylimidazolidin-2-one-1-yl)-5-carboxylic acid to its acid chloride followed by reaction of the acid chloride with a compound of formula II. |