发明名称 |
Method of treating CD4+ T cell lymphopenia in immuno-compromised patients |
摘要 |
The present invention is directed to methods of treating CD4+ T cell lymphopenia in HIV-infected patients. The methods include administering an effective mount of adenosine deaminase or related enzymatic material to a patient in need thereof. In preferred aspects of the invention, the method is employed in conjunction with HIV-infected patients having CD4+ T cell levels of less than about 200/ mu l. Effective amounts of the enzyme range from about 5 to about 50 IU/kg/week. In one particularly preferred aspect of the invention, the adenosine deaminase is conjugated to one or more strands of polyethylene glycol to prolonged activity in vivo.
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申请公布号 |
US5728560(A) |
申请公布日期 |
1998.03.17 |
申请号 |
US19960663685 |
申请日期 |
1996.06.14 |
申请人 |
ENZON, INC. |
发明人 |
SHORR, ROBERT G. L.;CLARK, MIKE A.;GODDARD, DAVID H. |
分类号 |
A61K38/46;A61K47/48;(IPC1-7):A61K38/43;C12N9/00;C12N9/78 |
主分类号 |
A61K38/46 |
代理机构 |
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主权项 |
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地址 |
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