| 摘要 |
<p>PROBLEM TO BE SOLVED: To efficiently produce the subject compounds, having a specificα/β- anomeric ratio and useful as an antiviral agent, etc., by reacting a protected specific carbohydrate with a suitable base, then reacting the resultant compound with a strong base and removing benzoyl protecting groups. SOLUTION: A protected carbohydrate represented by formula I (L is an eliminable group) is reacted with a suitable base represented by the formula BH B is a group represented by formula II [X is N or a group represented by C-R<4> (R<4> is H, a 1-4C alkyl, amino or a halogen) ; R" is H, a l-4C alkyl, etc.], a group represented by formula III, etc.} to provide a compound represented by formula IV (Rs are each benzoyl), which, as desired, is reacted with a strong base or a moderately strong base to eliminate benzoyl protecting groups. Thereby, a compound represented by formula IV (Rs are each H) is produced to thereby afford the objective 2'-deoxy-2',2'-difluoronucleoside represented by formula IV (Rs are each H or benzoyl) at about 1:1α/β-anomeric ratio.</p> |
