发明名称 |
Mixed agonists of the progesterone receptor and assays therefor |
摘要 |
A third class of PR-ligand (i.e. mixed agonist) is identified which induces a progesterone receptor conformation distinct from that induced by a PR agonist or antagonist. PR mixed agonists exhibit partial agonist activity which is influenced by cell context. These compounds provide useful pharmacological profiles for treating progesterone related diseases and/or conditions. Assays are provided to screen for PR mixed agonists. Molecular designs are provided to convert a PR antagonist to a PR mixed agonist. |
申请公布号 |
WO9805679(A3) |
申请公布日期 |
1998.03.12 |
申请号 |
WO1997US13754 |
申请日期 |
1997.08.05 |
申请人 |
DUKE UNIVERSITY |
发明人 |
MCDONNELL, DONALD, P.;WAGNER, BRANDEE, L. |
分类号 |
C07J1/00;C07J7/00;C07J41/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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