SEMI-SYNTHETIC SULPHAMINOHEPAROSANSULPHATES HAVING HIGH ANTI-METASTATIC ACTIVITY AND REDUCED HAEMORRHAGIC RISK

摘要

Sulphaminoheparosansulphates obtainable from the Escherichia coli K5 polysaccharide by deacetilation and the subsequent sulfation with the sulphuric anhydride/trimethylamine adduct carried out at 0 ~C, for times ranging from 0.25 to 2 hours and using a reactant/polysaccharide ratio (SO3 equivalents/available OH groups equivalents) equal to 5 have been found having high anti-metastatic activity and low anticoagulant activity.