发明名称 |
IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1 alpha , 3 alpha , 4 beta )]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE |
摘要 |
Improvements in the yield of the antiviral agent of formula (I) are obtained by employing Dess-Martin periodinane to convert the cyclopentol of formula (VI) to the cyclopentanone of formula (VIII) and the methylenation of this cyclopentanone to the compound of formula (XI) by use of a Nysted reagent, Tebbe reagent, or a reagent prepared from zinc powder, diiodomethane, lead powder or lead chloride, and titanium tetrachloride in a suitable solvent.
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申请公布号 |
WO9809964(A1) |
申请公布日期 |
1998.03.12 |
申请号 |
WO1997US15007 |
申请日期 |
1997.08.26 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BISACCHI, GREGORY, S.;SUNDEEN, JOSEPH, E. |
分类号 |
C07D473/00;(IPC1-7):C07D473/18 |
主分类号 |
C07D473/00 |
代理机构 |
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地址 |
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