SEMIPEPTOID FARNESYL PROTEIN TRANSFERASE INHIBITORS AND ANALOGS THEREOF
摘要
A farnesyl protein transferase (i.e., farnesyltransferase) inhibitors formed as peptoid and semipeptoid peptidomimetic compounds derived from a farnesyltransferase universal recognition tetrapeptide sequence CAAX (i.e., CAAX motif) and analogs thereof, and to the use of these compounds and analogs and ester derivatives thereof as chemotherapeutic agents in oncogenic or non-oncogenic Ras associated cancers and proliferative diseases.
申请公布号
WO9809641(A1)
申请公布日期
1998.03.12
申请号
WO1997US15157
申请日期
1997.08.28
申请人
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW;FRIEDMAN, MARK, M.;LEVITZKI, ALEXANDER;GILON, CHAIM;REUVENI, HADAS