| 摘要 |
PCT No. PCT/US93/12530 Sec. 371 Date Aug. 8, 1995 Sec. 102(e) Date Aug. 8, 1995 PCT Filed Dec. 22, 1993 PCT Pub. No. WO94/14775 PCT Pub. Date Jul. 7, 1994This invention relates to compounds of the formula:W-Z-(CR'R10)r-U-(CR'2)s-V-Awherein: <IMAGE>tly are absent or present as CO, CR'2, C(=CR'2), S(O)r, O, NR', CR'OR', CR'(OR'')CR'2, CR'2CR'(OR''), C(O)CR'2, CR'2C(O), CONR', NR'CO, OC(O), C(O)O, C(S)O, OC(S), C(S)NR', NR'C(S), S(O)rNR', NR'S(O)r, N=N, NR'NR', NR'CR'2, NR'CR'2, CR'2O, OCR'2, c 3BOND c, CR'=CR', or CR'(NR'R'')C(O); each r independently is 0 to 3; s is 0 to 2; each R' independently is H, C1-4alkyl, C3-7cycloalkyl-C0-4alkyl, or Ar-C0-4alkyl; each R'' independently is R', -C(O)R', or -C(O)OR15; R10 is as H, C1-4alkyl, or -NR'R'; each R15 independently is C1-4alkyl, C3-7cycloalkyl-C0-4alkyl, or AR-C0-4alkyl; R2 is present once or twice as C1-4alkyl, J-CO2R', CONR', SR', NR'R'', C1-4alkoxy, hydroxy, CN, CF3, halo, or <IMAGE> with the proviso that at least one R2 is J-CO2R; J is a single bond, -OCR'2-, -NR'CR'2-, CR'2-CR'2-, -CR'2-, -CR'=CR', or -C(O)NR'CR'2-; and each R14 independently is C1-4alkyl, C3-7cycloalkyl-C0-4alkyl, Ar-C0-4alkyl, C(O)R', CN, NO2, SO2R', or C(O)OR15; or a pharmaceutically acceptable salt thereof.
|
