发明名称 |
Enantiomeric enrichment of bicyclic alcohols |
摘要 |
There is disclosed a two-stage enzymatically catalyzed reaction for the selective preparation of the (R)-endo-isomer of norbornenol from a mixture containing all four stereo- and regioisomers of norbornenol, as well as the synthesis of the intermediate product comprising the enantiomerically enriched mono-ester of (R)-endo-norbornenol and a diacid, and of the enantiomerically enriched saturated alcohol (R)-endo-norborneol. There is also disclosed a method for the production of (R)-endo-norborne-2-ol, by chemical reduction of either the enantiomerically enriched monoester and subsequent hydrolysis, or by hydrolysis of the enantiomerically enriched monoester and then chemical reduction.
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申请公布号 |
US5726344(A) |
申请公布日期 |
1998.03.10 |
申请号 |
US19950515153 |
申请日期 |
1995.08.15 |
申请人 |
BEND RESEARCH, INC. |
发明人 |
WEST, J. BLAIR;DEVRIES, KEITH |
分类号 |
C07C69/013;(IPC1-7):C07C69/34 |
主分类号 |
C07C69/013 |
代理机构 |
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地址 |
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