| 摘要 |
PROBLEM TO BE SOLVED: To prepare a medicine, having low cytotoxicity, excellent suppressing actions on cell adhesion and useful as a suppressant, etc., for cancer metastasis by using specific lignans as an active ingredient. SOLUTION: This cell adhesion suppressant comprises lignans represented by the formula (R<1> to R<4> are each H, hydroxyl, an alkyl, a hydroxyalkyl or an alkoxy) as an active ingredient. Furthermore, the lignans are preferably obtained by carrying out the extraction treatment of, e.g. a leaf part of Thujopsis dolabrata Sieb. et Zucc. of the family Cupressaceae with water, an organic solvent such as toluene, an aqueous alcohol, etc., usually at 3-70 deg.C and the lignans are preferably blended in an amount of 1-70wt.% in the pharmaceutical preparation. The dose thereof for an adult is preferably 0.1-2,000mg at a time and daily and perorally administered in one to several portions. |
